The maiden launch of the Falcon I cleared the tower, but was lost moments later. Early, unconfirmed observations from the webcast suggest that the propulsion system failed, after which the rocket started rolling. The webcast was lost soon after. Here is one of the last images in the webcast from inside the rocket, which shows the rocket rolling.
SpaceX issued the following statement: "We had a successful liftoff and Falcon made it well clear of the pad, but unfortunately the vehicle was lost in the first stage burn. More information will be posted once we have had time to analyze the problem."
Unfortunately, failure is a sizeable part of the space business, and it is a shame that SpaceX has to take its share of lumps. However, the history of the industry suggests that SpaceX will be able to do a successful launch one of these attempts. The solution is persistence.